A retrospective analysis of the results obtained from the clinical chemistry laboratory for errors in the preanalytical phase has been carried out to summarize data regarding the frequency of the main factors affecting the preanalytical quality of results. Chemistry and laboratory medicine eflm working group for. First of all, poct testing is usually performed by clinical staff i. Clia compliance for preanalytic, analytic, and post. According to bd and clsi clinical and laboratory standards institute, formerly nccls, following is the correct order of draw during venipuncture will help to ensure accurate test results. Background laboratory testing is roughly divided into three phases. Quality assurance in the hematology laboratory is intended to ensure laboratory users of standardized, reliable test results 3 456 7. Most errors affecting laboratory test results occur in the preanalytical phase, primarily because of the difficulty in achieving standardized procedures for sample collection. Currently, preanalytical errors account for up to 70% of all mistakes made in laboratory diagnostics, most of which arise from problems in patient preparation, sample collection, transportation, and preparation for analysis and storage. Monitoring and reporting of preanalytical errors in laboratory. Most analytical errors have been attributed to the analytical phase.
Monitoring and reporting of preanalytical errors in. Preanalytical errors in medical laboratory meeqat general hospital, 25 october 2016 by prof. Currently, preanalytical errors account for up to 70% of all mistakes made in laboratory diagnostics, most of which arise from problems in patient preparation, sample. How to ensure the quality of preanalytical phase and point. Most errors affecting laboratory test results occur in the preanalytical. Identification of the types of preanalytical errors in the. The focus is on the experience of a working group of the international federation of clinical chemistry and laboratory medicine ifcc in developing a model of. Preanalytical errors in laboratory their consequences and. Identification of preanalytical errors in the clinical laboratory of north indian tertiary care hospital. To evaluate the major causes of preanalytical errors in medical laboratory of a tertiary care.
Identification of the types of preanalytical errors in the clinical. Preanalytical errors in laboratory their consequences. The oneweek observation focused on 73 nurses drawing blood from 337 patients. Recently, the literature has defined not only preanalytical errors, but prepre, pre, post, and postpostanalytical errors. Pdf download for preanalytical errors in medical laboratories.
Preanalytical errors in medical laboratories preanalytical errors in medical laboratories ashishkumar soni qms manager. In the clinical laboratory all errors must be measured and controlled, from the obvious ones to those that do not originate in the laboratory 1, by means of indicators providing an objective assessment of the problem and, when appropriate, by carrying out comparisons between different laboratories and different periods of time. The potential to affect assays and proposed verification and validation processes for the clinical laboratory raffick a. It accounts for over 60% of blood sample rejections in the laboratory and is the most common preanalytical.
Oct 11, 2012 various types of errors that we, as clinical biochemists, encounter in the laboratory are classified as preanalytical, analytical, and postanalytical, depending upon the time of presentation. Clinical laboratory and biomedical science related news, abstracts and images for medical laboratory professionals, students and other laboratory geeks. Preanalytical errors there is now incontrovertible evidence that the preanalytical. Pre analytical variables account for 3275% of laboratory errors, and encompass the time from when thetest is ordered by the physician until the sample is ready for analysis. Manual spectrophotometers, such as the pd 303 spectrophotometer apel. We will concentrate on the preanalytical errors which include specimen type selection, blood collection, blood collection equipments and the. Clinical laboratory diagnostics download ebook pdf, epub. The preanalytical phase is an important component of laboratory medicine 1.
Failures to consider these factors do constitute errors. A new and effective way for preventing preanalytical laboratory errors. There have been numerous international efforts to raise awareness of the importance of the extraanalytical phase. Pdf preanalytical errors in clinical chemistry laboratory. Clinical biochemistry laboratory rejection rates due to. There are pre analytical, analytical and post analytical factors that contribute to accurate test results in clinical laboratories. Marien, weiden and amberg, germany anamaria simunic. Some years ago, a preanalytical errors recording software was developed for easing and standardizing the activity of recording preanalytical errors 8. Pre analytical errors in clinical chemistry laboratory of a tertiary care hospital article pdf available in international journal of scientific research 74. Reasons of pre analytical errors it is found that there are some major reasons that cause errors in pre analytical phase of laboratory testing like unawareness among healthcare professionals, do not follow the guidelines, carelessness during the sample collection, handling, storage and transportation.
For obtaining reliable test results, the prevention and detection of errors at all steps. According to bd and clsi clinical and laboratory standards institute, formerly nccls, following is the correct order of draw during. Factors affecting the usefulness of laboratory data may arise in any of the preanalytical, analytical or postanalytical phase of the testing cycle. Laboratory data are broadly used in medical practice thus laboratory errors have a great impact on patient safety. Preanalytical phase errors have been found at the majority of the total errors 4668. Preanalytical errors have previously been shown to contribute a significant. Errors in clinical laboratories or errors in laboratory medicine. The study intends to observe the frequency of preanalytical phase errors both inside and outside the clinical laboratory according to certain quality indicators qis.
The hidden flaws in total testing, sushma bj and shrikant c. Quality indicators to detect preanalytical errors in laboratory testing. The aim is to highlight the multifactorial human dependent erroneous stage that affects the biochemical routine test results, which can be easily prevented with awareness and laboratory staff education. Preanalytical errors are quite frequent in the area of pointofcare testing poct. A new and effective way for preventing preanalytical laboratory. It seems that people want to believe that analytical errors arent as frequent as the preanalytical and postanalytical errors. Feb 15, 2014 preanalytical errors contd order of draw. Department of medical laboratory diagnostics, clinical hospital sveti duh, zagreb, croatia unauthenticated download date 2419 8. Preanalytical variables account for 3275% of laboratory errors, and encompass the time from when the test is ordered by the physician until the sample is ready for analysis. Unfortunately, according to the literature which comprises the process from the. Factors affecting the usefulness of laboratory data may arise in any of the preanalytical, analytical or post.
The preanalytical phase is an important component of laboratory medicine and errors arising in this phase affect the validity of laboratory results. In a previous study by the association for clinical biochemistry and laboratory medicine preanalytical specialist interest group acbsigpa, we have shown that there is a wide variation in the definition, repertoire and collection methods for preanalytical qis. In the clinical laboratory all errors must be measured and controlled, from the obvious ones to those that do not originate in the laboratory 1, by means of indicators providing an objective assessment of the. In clinical diagnostic laboratories, the total testing process includes every step from the.
Under handbook, you will find a description of the most typical preanalytical errors in blood gas testing and tips on how to avoid them. The significant contributions to errors in the postanalytic phase are a failure in reporting, erroneous validation of analytical data, and incorrect data entry. Reduction of preanalytical errors in laboratory by. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. The recent surveys on laboratory errors say that in the delivery of laboratory testing, errors occur more frequently in preanalytical and postanalytical phases.
Errors in preanalytical phase occupied for almost half of total errors in clinical laboratory, and the causes are related to medical staffs quality awareness and behaviors. Prevalence of preanalytical errors in clinical chemistry. Most errors affecting laboratory test results occur in the pre analytical phase 4668. Consequently the frequency of errors in clinical lab oratories. Study on preanalytical errors in a clinical biochemistry laboratory. D, in accurate results in the clinical laboratory second edition, 2019. Pdf preanalytical errors in clinical chemistry laboratory of a. Various types of errors that we, as clinical biochemists, encounter in the laboratory are classified as preanalytical, analytical, and postanalytical, depending upon the time of presentation. Identification of preanalytical errors in the clinical laboratory of.
Moushumi saikia, department of clinical laboratory at apollo hospitals. Reducing preanalytical errors whitehat communications. This may be due to the lack amongst healthcare professionals of both education and. Laboratory testing in clinical trials laboratory medicine is conventionally defined as a science focused on generation of clinical. Preanalytical variables and factors that interfere with.
However, recent studies have shown that up to 70% of analytical errors reflect the preanalytical phase. Clinical biochemistry preanalytical aspects of laboratory. Review of medical errors in laboratory diagnostics and where. Studies indicate that preanalytical errors contribute a major proportion of errors in laboratory processes and contribute to a number of risks related to the patient safety. A report by bonini and colleagues found that preanalytical errors predominated in the laboratory, ranging from 31. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Out of these three groups of error, pre analytical. In order to reduce the preanalytical errors in our hospital, we established and applied a training system to improve the situation. In a previous study by the association for clinical biochemistry and laboratory medicine preanalytical specialist interest group acbsigpa, we have shown that there is a wide variation in. Laboratory testing in clinical trials laboratory medicine is conventionally defined as a science focused on generation of clinical information through analysis of concentration, composition and or structure of many different analytes in various biological fluids 12.
While the likelihood of variation in any of the three phases is not negligible, the vast majority. Analytical errors are often narrowly defined as errors in the box, which occur only within the laboratory and sometimes only during the actual analysis step when the specimen is inside the instrument. We will concentrate on the preanalytical errors which include specimen type selection, blood collection, blood collection equipments and the factors in terfering with. The laboratory testing process is divided into the pre analytical, analytical and postanalytical phases. In fact, it is estimated that 75 % of all laboratory medicine. Timeliness and the incorrect interpretation of diagnostic or laboratory tests were responsible for a significant percentage of errors in ambulatory and emergency department settings. Prevalence of preanalytical errors in clinical chemistry diagnostic. Errors in clinical laboratories or errors in laboratory. Preanalytical errors there is now incontrovertible evidence that the preanalytical phase is the major source of errors in laboratory testing, when used for either diagnostic 11 or research 12 purposes. Oct 21, 2016 preanalytical variables account for 3275% of laboratory errors, and encompass the time from when the test is ordered by the physician until the sample is ready for analysis. Analytical errors are often narrowly defined as errors in the box, which occur only. Reducing preanalytical laboratory sample errors through.
In fact, it is estimated that 75 % of all laboratory medicine errors are preanalytical errors 2. Download the introduction to preanalytical variables editorial in. The preanalytical phase comprises all processes from the time a laboratory. Preanalytical errors in clinical chemistry laboratory. Postanalytical phase an overview sciencedirect topics. Preanalytical errors in clinical chemistry laboratory of a tertiary care hospital. Preanalytical errors management in the clinical laboratory. Mar 09, 2017 preanalytical errors in medical laboratory meeqat general hospital, 25 october 2016 by prof. Preanalytical variables and factors that interfere with the. Clinical institute of chemistry, clinical unit for medical biochemistry and toxicology, university hospital center sestre.
Preanalytical errors in blood gas testing anamaria simundic zagreb, croatia. Laboratory errors can be defined as any defect from ordering tests to reporting results and appropriately interpreting and reacting on these. Clia compliance for preanalytic, analytic, and postanalytic. Through this video she explained about analytical errors in clinical laboratory which affects patients safety. Errors in clinical labora tories or errors in laboratory medicine. Preanalytical errors in clinical chemistry laboratory of. According to several studies, a large number of errors involving laboratory medicine happen during the preand postanalytical testing phases 1. Pdf preanalytical phase in clinical chemistry laboratory. Preanalytical errors and their impact on tests in clinical. Quality indicators to detect preanalytical errors in. Potential preanalytical and analytical vulnerabilities in. Preanalytical variation includes all the steps that occur from test ordering until right before sample analysis. Giuseppe lippi, laura sciacovelli, anamaria simundic and. To evaluate the major causes of preanalytical errors in medical laboratory of a.
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